(091) Association between use of Furosemide and Risk of Parkinson’s disease

Background: New treatments for Parkinson’s disease (PD) are needed and drug repurposing may aid in this. Furosemide, a diuretic commonly used in heart and renal failure, was associated with lower risk of PD in French population. Confirmation of this association is important.

Objectives: We studied the association between furosemide use and risk of PD in a Finnish nationwide nested case-control study, and an indication-restricted case-control study among persons with heart failure or renal failure.

Methods: 19 568 PD cases and 130 156 sex, age, and region-matched controls from the register-based Finnish study on PD (FINPARK, diagnosed 1999-2015) were included. A case-control study restricted to those with heart failure and renal failure was conducted, including 1 222 PD cases and 4 766 controls, matched on age, sex, region and duration of heart or renal failure. Furosemide use was identified from Prescription register (1995-2015), and exposure to furosemide was determined as ever, at least 3, 5 or 8 years before the outcome.

Results: Regardless of the study population or exposure assessment period, furosemide use was not associated with risk of PD (e.g., OR 0.96; 95% CI 0.83-1.12 for furosemide use at least 5 years before the diagnosis in indication-restricted study and OR 0.99; 95% CI 0.93-1.06 in the entire FINPARK cohort).

Conclusions: Our nationwide indication-restricted case-control study of people with PD having heart failure and renal failure found no robust evidence on the association between the use of furosemide and risk of PD.