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Nervous system conditions and treatments

Session: Poster Session A

(314) Mapping the Epidemiological burden of active and lifetime epilepsy in Asian Countries: A Systematic review and Meta-analysis

Monday, August 26, 2024
8:00 AM – 6:00 PM CEST
Location: Convention Hall II

    Presenting Author(s)

  • Mohammed Safeer V S, PhD

    Research Scholar
    National Institute of Pharmaceutical Education and Research (NIPER), S.A.S Nagar, India, India

    • Co-Author(s)

  • DB

    Dipika Bansal, MD, DM

    National Institute of Pharmaceutical Education and Research (NIPER). S.A.S. Nagar
    Mohali, India

  • JS

    Jitendra Kumar Sahu

    Professor
    Pediatric Neurology Unit, Advanced Pediatric Centre, Postgraduate Institute of Medical Education & Research, Chandigarh, India, India

Background: In the current era of the World Health Organization's Intersectoral Global Action Plan on Epilepsy and Other Neurological Disorders 2022-2031 (IGAP), precise and updated estimates of epilepsy burden are vital in formulating policies to improve the care of persons with epilepsy, especially in Asian countries with significant treatment gap.

Objectives: This study aimed to consolidate the available data and quantify epilepsy prevalence and incidence estimates in Asian countries using meta-analytic approach.

Methods: We systematically searched PubMed, Embase, Ovid, and Scopus databases from inception until September 2023 for studies reporting epilepsy prevalence and incidence in Asian countries. We applied random effects meta-analysis to generate the pooled prevalence and incidence using the meta package in R. Additionally, we performed a subgroup meta-analysis to explore the potential sources of heterogeneity. Publication bias was assessed using funnel plot and Egger's regression tests. Leave one out sensitivity analysis was performed to evaluate the impact of a single study on the pooled estimates. A meta-regression analysis was conducted to examine the trend of epilepsy over time

Results: A total of 98 studies with 10,06,30,206 participants were included in this meta-analysis. The pooled prevalence was 5.6 per 1000 (95% confidence interval (CI) 4.4-6.8) for active epilepsy and 6.8 per 1000 (95% CI 5.7-7.9) for lifetime epilepsy. The pooled incidence rate of epilepsy was 52.5 per 100,000 person-years (95% CI 42.7-79.4). The subgroup analysis revealed a higher prevalence of active epilepsy (6.7/1000) and lifetime epilepsy (8.6/1000) in West Asia than in other regions. The funnel plot and Egger's test (p-value = < 0.0001) revealed publication bias for active epilepsy

Conclusions: Our findings highlighted a high prevalence of active and lifetime epilepsy in West Asia and emphasize the necessity of implementing and formulating specific strategies to tackle the epilepsy burden in this region. Furthermore, high-quality epidemiological studies incorporating economic burdens and comorbidities associated with epilepsy in Asia are still needed